Digital and Analog
Biomarkers in AD

Polish-Japanese Academy of Information Technology

Prof. Maria Barcikowska; Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences

Department of Neurodegenerative Disorders, headed by prof. Maria Barcikowska was established as an independent unit in 2000. The research scopes of the Department encompass diagnosis, treatment of the vast spectrum of neurodegenerative disorders, as well as the basic research in the field of genomics, transcriptomics, biochemistry and cell biology. The Department is a center of differential diagnosis of Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), frontotemporal dementia (FTD), Lewy body dementia (LBD), vascular dementia (VD), and other older age neurodgenerative conditions.
 
Two closely co-operating units form the Department: Alzheimer's Disease Division of the Clinic of Neurology, localized in the Central Clinical Hospital of the Ministry of Internal Affairs and Administration (head: prof. Tomasz Gabryelewicz MD, PhD, DSc) and Laboratory of Neurogenetics (head: prof. Cezary Żekanowski PhD, DSc), localized in the main MRC building.
  1. Granular Computing to Forecast Alzheimer’s Disease Distinctive Individual Development
    Przybyszewski, Andrzej W., et al. Asian Conference on Intelligent Information and Database Systems. Singapore: Springer Nature Singapore, 2023.
  2. Multi-granular Computing Can Predict Prodromal Alzheimer's Disease Indications in Normal Subjects
    Przybyszewski, Andrzej W. International Conference on Computational Science. Cham: Springer Nature Switzerland, 2023.
  3. Machine Learning and Eye Movements Give Insights into Neurodegenerative Disease Mechanisms
    Przybyszewski, Andrzej W., et al., Sensors 23.4 (2023): 2145.
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  4. Rough Set Rules (RSR) Predominantly Based on Cognitive Tests Can Predict Alzheimer’s Related Dementia
    Przybyszewski, Andrzej W., et al. Intelligent Information and Database Systems: 14th Asian Conference, ACIIDS 2022, Ho Chi Minh City, Vietnam, November 28–30, 2022, Proceedings, Part I. Cham: Springer International Publishing, 2022.
  5. AI Classifications Applied to Neuropsychological Trials in Normal Individuals that Predict Progression to Cognitive Decline
  6. Filipek-Gliszczyńska A, Barczak A, Budziszewska M, Mandecka M, Gabryelewicz T, Barcikowska M. The Erlangen Score Algorithm in the diagnosis and prediction of the progression from subjective cognitive decline and mild cognitive impairment to Alzheimer-type dementia. Folia Neuropathol, 2018, 56:88-96
  7. Baranowska-Bik A, Kalisz M, Martyńska L, Wolińska-Witort E, Styczyńska M, Chodakowska-Żebrowska M, Barcikowska M, Baranowska B, Bik W. - Plasma adiponectin array in women with Alzheimer's disease. Endokrynol Pol, 2018, 69: 550-559
  8. Wezyk M, Spólnicka M, Pośpiech E, Pepłońska B, Zbieć-Piekarska R, Ilkowski J, Styczyńska M, Barczak A, Zboch M, Filipek-Gliszczynska A, Skrzypczak M, Ginalski K, Kabza M, Makałowska I, Barcikowska-Kotowicz M, Branicki W, Żekanowski C. - Hypermethylation of TRIM59 and KLF14 Influences Cell Death Signaling in Familial Alzheimer's Disease. Oxid Med Cell Longev. 2018: 6918797.
  9. Peplonska B, Berdynski M, Mandecka M, Barczak A, Kuzma-Kozakiewicz M, Barcikowska M, Zekanowski C. - TREM2 variants in neurodegenerative disorders in the Polish population. Homozygosity and compound heterozygosity in FTD patients. Amyotroph Lateral Scler Frontotemporal Degener. 2018, 19:407-412.
  10. Spólnicka M, Pośpiech E, Pepłońska B, Zbieć-Piekarska R, Makowska Ż, Pięta A, Karłowska-Pik J, Ziemkiewicz B, Wężyk M, Gasperowicz P, Bednarczuk T, Barcikowska M, Żekanowski C, Płoski R, Branicki W. - DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups. Int J Legal Med. 2017 Jul 19. doi: 10.1007/s00414-017-1636-0. 
  11. Mandecka M, Budziszewska M, Barczak A, Pepłońska B, Chodakowska-Żebrowska M, Filipek-Gliszczyńska A, Nesteruk M, Styczyńska M, Barcikowska M, Gabryelewicz T. - Association between Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, APOE Genotypes and Auditory Verbal Learning Task in Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's Disease. J Alzheimers Dis. 2016 Jul 29;54(1):157-68. doi: 10.3233/JAD-160176.
  12. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease
    Christopher W Medway, Samer Abdul-Hay, Tynickwa Mims, Li Ma, Gina Bisceglio, Fanggeng Zou, Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Joanna Siuda, Zbigniew K Wszolek, Owen A Ross, Minerva Carrasquillo, Dennis W Dickson, Neill Graff-Radford, Ronald C Petersen, Nilüfer Ertekin-Taner, Kevin Morgan, Guojun Bu, Steven G Younkin Mol Neurodegener. 2014; 9: 11. Published online 2014 Mar 10. doi: 10.1186/1750-1326-9-11 
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  13. LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD)
    Sarah Lincoln, Mariet Allen, Claire L. Cox, Louise P. Walker, Kimberly Malphrus, Yushi Qiu, Thuy Nguyen, Christopher Rowley, Naomi Kouri, Julia Crook, V. Shane Pankratz, Samuel Younkin, Linda Younkin, Minerva Carrasquillo, Fanggeng Zou, Samer O. Abdul-Hay, Wolfdieter Springer, Sigrid B. Sando, Jan O. Aasly, Maria Barcikowska, Zbigniew K. Wszolek, Jada M. Lewis, Dennis Dickson, Neill R. Graff-Radford, Ronald C. Petersen, Elizabeth Eckman, Steven G. Younkin, Nilüfer Ertekin-Taner PLoS One. 2013; 8(6): e64164. Published online 2013 Jun 4. doi: 10.1371/journal.pone.0064164
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  14. A Patient with Posterior Cortical Atrophy Possesses a Novel Mutation in the Presenilin 1 Gene
    Emilia J. Sitek, Ewa Narożańska, Beata Pepłońska, Sławomir Filipek, Anna Barczak, Maria Styczyńska, Krzysztof Mlynarczyk, Bogna Brockhuis, Erik Portelius, Dorota Religa, Maria Barcikowska, Jarosław Sławek, Cezary Żekanowski PLoS One. 2013; 8(4): e61074. Published online 2013 Apr 12. doi: 10.1371/journal.pone.0061074   
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  15. Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen, Fanggeng Zou, High Seng Chai, Curtis S Younkin, Richard Miles, Asha A Nair, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Gina Bisceglio, Alexandra I Ortolaza, Ryan Palusak, Sumit Middha, Sooraj Maharjan, Constantin Georgescu, Debra Schultz, Fariborz Rakhshan, Christopher P Kolbert, Jin Jen, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner Mol Neurodegener. 2012; 7: 13. Published online 2012 Apr 11. doi: 10.1186/1750-1326-7-13 
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  16. Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease
    Laura Buizza, Giovanna Cenini, Cristina Lanni, Giulia Ferrari-Toninelli, Chiara Prandelli, Stefano Govoni, Erica Buoso, Marco Racchi, Maria Barcikowska, Maria Styczynska, Aleksandra Szybinska, David Allan Butterfield, Maurizio Memo, Daniela Uberti PLoS One. 2012; 7(1): e29789. Published online 2012 Jan 5. doi: 10.1371/journal.pone.0029789 
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  17. Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
    Minerva M Carrasquillo, Olivia Belbin, Talisha A Hunter, Li Ma, Gina D Bisceglio, Fanggeng Zou, Julia E Crook, V Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Zbigniew K Wszolek, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Peter Passmore, Kevin Morgan, Steven G Younkin Mol Neurodegener. 2011; 6: 54. Published online 2011 Jul 28. doi: 10.1186/1750-1326-6-54 
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  18. N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI)
    Jerzy Walecki, Maria Barcikowska, Jarosław B. Ćwikła, Tomasz Gabryelewicz Med Sci Monit. 2011; 17(12): MT105–MT111. Published online 2011 Dec 1. doi: 10.12659/MSM.882112 
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  19. Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth, Denise Harold, …, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, V Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Zbigniew K Wszolek, et. al. Nat Genet. 2011 May; 43(5): 429–435. Published online 2011 Apr 3. doi: 10.1038/ng.803 
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  20. Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions
    Minerva M. Carrasquillo, Olivia Belbin, Talisha A. Hunter, Li Ma, Gina D. Bisceglio, Fanggeng Zou, Julia E. Crook, V. Shane Pankratz, Sigrid B. Sando, Jan O. Aasly, Maria Barcikowska, Zbigniew K. Wszolek, Dennis W. Dickson, Neill R. Graff-Radford, Ronald C. Petersen, Kevin Morgan, Steven G. Younkin J Alzheimers Dis. Author manuscript; available in PMC 2012 Nov 5. Published in final edited form as: J Alzheimers Dis. 2011; 24(4): 751–758. doi: 10.3233/JAD-2011-101932 
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  21. PIN1 gene variants in Alzheimer's disease
    Aleksandra Maruszak, Krzysztof Safranow, Katarzyna Gustaw, Beata Kijanowska-Haładyna, Katarzyna Jakubowska, Maria Olszewska, Maria Styczyńska, Mariusz Berdyński, Andrzej Tysarowski, Dariusz Chlubek, Janusz Siedlecki, Maria Barcikowska, Cezary Żekanowski BMC Med Genet. 2009; 10: 115. Published online 2009 Nov 12. doi: 10.1186/1471-2350-10-115 
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  22. Intra-Familial Clinical Heterogeneity due to FTLD-U with TDP-43 Proteinopathy Caused by a Novel Deletion in Progranulin Gene (PGRN)
    Tomasz Gabryelewicz, Mario Masellis, Mariusz Berdynski, Juan M. Bilbao, Ekaterina Rogaeva, Peter St George-Hyslop, Anna Barczak, Krzysztof Czyzewski, Maria Barcikowska, Zbigniew Wszolek, Sandra E. Black, Cezary Zekanowski J Alzheimers Dis. Author manuscript; available in PMC 2016 Sep 30. Published in final edited form as: J Alzheimers Dis. 2010; 22(4): 1123–1133. doi: 10.3233/JAD-2010-101413 
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  23. Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish Population
    Robert P. Erickson, Katherine Larson-Thome, Lyndon Weberg, Aleksandra Szybinska, Malgorzata Mossakowska, Maria Styczynska, Maria Barcikowska, Jacek Kuznicki Neurosci Lett. Author manuscript; available in PMC 2009 Dec 12. Published in final edited form as: Neurosci Lett. 2008 Dec 12; 447(2-3): 153–157. Published online 2008 Sep 24. doi: 10.1016/j.neulet.2008.09. 
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  24. Relation between the onset of AD and the polymorphism of PRNP, gene for protein in PrPc
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